Takanori Matsui Selected Research

Nucleotide Aptamers

1/2021	DNA aptamer raised against receptor for advanced glycation end products suppresses renal tubular damage and improves insulin resistance in diabetic mice.
1/2021	DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice.
10/2020	Association of advanced glycation end products with sarcopenia and frailty in chronic kidney disease.
1/2018	Therapeutic Potential of DNA-aptamers Raised Against AGE-RAGE Axis in Diabetes-related Complications.
11/2017	RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice.
1/2017	RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy.
1/2015	DNA Aptamer Raised against Advanced Glycation End Products Prevents Abnormalities in Electroretinograms of Experimental Diabetic Retinopathy.
4/2014	DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice.
2/2014	DNA aptamer raised against advanced glycation end products inhibits neointimal hyperplasia in balloon-injured rat carotid arteries.
9/2013	DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy.

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Takanori Matsui Research Topics

Disease

28	Diabetic Nephropathies (Diabetic Nephropathy) 01/2021 - 07/2009
26	Atherosclerosis 05/2020 - 01/2006
24	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2018 - 05/2005
23	Neoplasms (Cancer) 08/2021 - 10/2004
23	Stomach Neoplasms (Stomach Cancer) 09/2020 - 10/2003
21	Cardiovascular Diseases (Cardiovascular Disease) 12/2020 - 01/2006
17	Inflammation (Inflammations) 01/2020 - 01/2006
17	Diabetic Angiopathies (Diabetic Angiopathy) 10/2016 - 11/2005
13	Type 2 Diabetes Mellitus (MODY) 03/2021 - 03/2007
13	Insulin Resistance 01/2021 - 08/2007
11	Neoplasm Metastasis (Metastasis) 01/2021 - 11/2008
11	Hyperglycemia 07/2020 - 02/2006
9	Body Weight (Weight, Body) 01/2021 - 01/2013
9	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 04/2006
7	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2014 - 06/2006
6	Vascular System Injuries 01/2018 - 06/2007
5	Fibrosis (Cirrhosis) 03/2021 - 02/2011
5	Chronic Renal Insufficiency 10/2020 - 11/2009
4	Hemorrhage 11/2022 - 02/2022
4	Thrombosis (Thrombus) 08/2021 - 03/2008
4	Melanoma (Melanoma, Malignant) 01/2021 - 04/2014
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 07/2020 - 02/2006
4	Hypertension (High Blood Pressure) 07/2020 - 01/2006
4	Albuminuria 04/2020 - 11/2016
4	Colonic Neoplasms (Colon Cancer) 12/2019 - 10/2004
4	Proteinuria 08/2012 - 05/2009
4	Ascites 01/2009 - 10/2003
3	Hepatocellular Carcinoma (Hepatoma) 09/2021 - 05/2006
3	Adenocarcinoma 11/2020 - 07/2007
3	Obesity 02/2020 - 05/2011
3	Hypoglycemia (Reactive Hypoglycemia) 02/2020 - 12/2012
3	Pathologic Neovascularization 01/2018 - 05/2006
3	Dehydration (Water Stress) 10/2015 - 10/2007
3	Coronary Artery Disease (Coronary Atherosclerosis) 05/2008 - 01/2006
3	Uveitis 09/2007 - 02/2007
2	Fistula 04/2022 - 02/2022

Drug/Important Bio-Agent (IBA)

85	Advanced Glycation End ProductsIBA 08/2021 - 08/2005
42	pigment epithelium-derived factorIBA 08/2021 - 05/2005
18	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2006
15	Receptor for Advanced Glycation End ProductsIBA 01/2021 - 11/2005
14	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2021 - 11/2005
12	Biomarkers (Surrogate Marker)IBA 07/2020 - 03/2007
11	Nucleotide AptamersIBA 01/2021 - 07/2007
10	Paclitaxel (Taxol)FDA LinkGeneric 01/2016 - 10/2003
9	NADPH Oxidases (NAD(P)H oxidase)IBA 08/2021 - 06/2007
8	Glucose (Dextrose)FDA LinkGeneric 03/2021 - 08/2009
8	Blood Glucose (Blood Sugar)IBA 01/2021 - 03/2010
7	CreatinineIBA 01/2021 - 09/2009
7	Telmisartan (Micardis)FDA Link 01/2020 - 11/2005
7	Insulin (Novolin)FDA Link 01/2020 - 09/2009
7	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2020 - 06/2007
7	Angiotensin IIIBA 06/2019 - 08/2005
7	Glycoproteins (Glycoprotein)IBA 03/2011 - 07/2007
6	Cisplatin (Platino)FDA LinkGeneric 09/2020 - 11/2005
6	Retinaldehyde (Retinal)IBA 09/2014 - 07/2006
5	GlyceraldehydeIBA 12/2021 - 12/2012
5	DNA (Deoxyribonucleic Acid)IBA 11/2020 - 07/2007
5	LigandsIBA 10/2018 - 11/2009
5	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2013 - 01/2010
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2009 - 02/2007
4	Uric Acid (Urate)IBA 01/2019 - 06/2006
4	AlbuminsIBA 01/2018 - 01/2010
4	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2013 - 06/2007
4	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 01/2013 - 01/2008
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2011 - 01/2008
4	Nifedipine (Adalat)FDA LinkGeneric 07/2010 - 01/2006
4	PPAR gammaIBA 07/2010 - 01/2008
4	Fluorouracil (Carac)FDA LinkGeneric 11/2006 - 11/2003
3	Peptides (Polypeptides)IBA 03/2021 - 03/2010
3	HMGB1 Protein (HMG1)IBA 01/2021 - 12/2009
3	Docetaxel (Taxotere)FDA Link 09/2020 - 01/2012
3	Messenger RNA (mRNA)IBA 07/2020 - 09/2007
3	Dipeptidyl-Peptidase IV InhibitorsIBA 07/2020 - 12/2011
3	Streptozocin (Streptozotocin)FDA Link 07/2020 - 01/2013
3	oxidized low density lipoproteinIBA 07/2020 - 05/2007
3	Sodium-Glucose Transport ProteinsIBA 04/2020 - 11/2016
3	AdiponectinIBA 01/2020 - 02/2008
3	HDL CholesterolIBA 01/2020 - 09/2009
3	Cell Surface ReceptorsIBA 01/2018 - 02/2015
3	sulforaphaneIBA 01/2018 - 09/2014
3	AntibodiesIBA 01/2018 - 09/2007
3	Capecitabine (Xeloda)FDA Link 01/2018 - 07/2016
3	S-1 plus cisplatinIBA 01/2018 - 01/2012
3	Nuclear Antigens (Extractable Nuclear Antigens)IBA 11/2017 - 02/2014
3	XELOXIBA 01/2017 - 07/2016
3	Monoclonal AntibodiesIBA 01/2017 - 11/2006
3	LipidsIBA 05/2015 - 11/2009
3	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 05/2015 - 07/2006
3	C-Reactive ProteinIBA 02/2012 - 05/2006
3	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 07/2010 - 01/2008
3	Angiotensin II Type 1 Receptor BlockersIBA 01/2008 - 01/2008

Therapy/Procedure

15	Therapeutics 11/2022 - 06/2004
7	Neoadjuvant Therapy 09/2020 - 01/2012
7	Drug Therapy (Chemotherapy) 04/2015 - 11/2003
6	Adjuvant Chemotherapy 01/2019 - 11/2006
3	Gastrectomy 01/2019 - 01/2016
3	Light Coagulation 03/2011 - 03/2007
2	Ligation 11/2022 - 03/2008
2	Renal Dialysis (Hemodialysis) 04/2022 - 01/2016
2	Surgical Instruments (Clip) 04/2022 - 02/2022